• Publié par : Denis CHRETIEN
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Sophie Blestel

Tél. 02 99 84 71 68

Depuis 2008 :

Institut National de Recherche en Informatique et en Automatique (INRIA), et UMR 6026 Interactions Cellulaires et Moléculaires

  • Etudiante en thèse (école doctorale MATISSE), sous la direction de Charles Kervrann (équipe SERPICO, INRIA, Rennes), et la co-direction de Denis Chrétien (équipe TIPs) :
    Individualisation d'assemblages macromoléculaires dans des tomogrammes obtenus par cryo-microscopie électronique
    .

2007-2008 :

Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA)

  • Master recherche Signal Tramp Image (STI) spécialité image.
    Stage de 5 mois à l’Irisa dans l’équipe Vista, en collaboration avec l'équipe TIPs :
    Modélisation statistique et segmentation d'images de microscopie électronique à trois dimensions
    .

2002-2007 :

Institut National des Sciences Appliquées de Rennes

  • 2005-2007 : Cycle ingénieur en Electronique et Informatique Industrielle.
    • Stage de 6 mois à l’Irisa dans l’équipe Visages :
      Développement d’un système de neuronavigation pour la stimulation magnétique transcrânienne (C++, python).
  • 2002 - 2004 : Cycle préparatoire.

Publications

  • Conditional Random Fields for tubulin-microtubule segmentation in cryo-electron tomography
    Kervrann C., Blestel S., and D. Chrétien
    Proceedings of the IEEE International Conference on Image Processing (ICIP 2014), Paris, Pages 1-4,  October 2014.
  • Single versus dual-axis cryo-electron tomography of microtubules assembled in vitro: Limits and perspectives
    Guesdon A., Blestel S., Kervrann C. and D. Chrétien
    Journal of Structural Biology, 2013, 1:169-178.
  • A Fourier-based method for detecting curved microtubule centers: Application to straightening of cryo-electron microscope images
    Blestel, S., Kervrann, C., and D. Chrétien
    Proceedings of the IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2009. pp. 298-301.

Brevet

  • TubuleJ (2011)
    IDDN.FR.001.240023.000.S.P.2011.000.21000
    Blestel S., A. Guesdon, C. Kervrann and D. Chrétien
  • Système de neuronavigation pour la stimulation magnétique transcrânienne (2007)
    Blestel S., V. Gratsac, P. Hellier
    IDDN.FR.001.470037.000.S.P.2007.000.31230

Conférences

  • How does GTP-hydrolysis destabilize the microtubule lattice?
    Guesdon A., Blestel, S., Kervrann, C., and D. Chrétien
    12th Congres of the French Society for Microscopy, Strasbourg, 27 June - 1st July 2011
    Poster abstracts pp. 271-272.
  • Interaction of +TIPs with microtubule ends
    Coquelle F.M.,  A. Guesdon, M. Angevin, T. Chenuel, M. Chrétien, C. Heichette, S. Blestel, C. Kervrann, I. Arnal, and D. Chrétien
    12th Congres of the French Society for Microscopy, Strasbourg, 27 June - 1st July 2011
    Poster abstracts pp. 269-270.
  • Cryo-electron tomography of macromolecular assemblies: from quantum dots to 3D crystals of proteins
    Guesdon A., F.M. Coquelle, S. Blestel, E. Pollet, B. Vitre, M. Angevin, C. Heichette, I. Arnal, C. Kervrann and D. Chrétien
    12th Congres of the French Society for Microscopy, Strasbourg, 27 June - 1st July 2011
    Poster abstracts pp. 236-237.
  • Three dimensional reconstruction of 14 protofilaments GMPCPP-microtubules using TubuleJ
    Guesdon A., S. Blestel, C. Heichette, C. Kervrann and D. Chrétien
    Inserm Workshop "Microtubules Dynamics in Cell Migration", Saint-Raphaël, 14-15 September 2010, France.
    Poster.
  • Ultrastructural analysis of wild-type and mutant axonemes in Paramecium by cryo-electron tomography.
    Fisch C.R., B. Desforges, J. Jerber, N. Lebreton, S. Blestel, A. Guesdon, C. Heichette, C. Kervrann, D. Chrétien, P. Dupuis-Williams
    Embo Meeting Barcelona 2010, Barcelona, Spain, 4-7 september 2010.
    Poster.
  • Three-dimensional reconstruction of 14 protofilaments GMPCPP-microtubules using TubuleJ
    Guesdon A., Blestel S., Heichette C., Kervrann C. and D. Chrétien.
    EMBO Conference Series "Microtubules, Structure, Regulation and Functions", European Molecular Biology Laboratory, Heidelberg, Allemagne, 2-5 June 2010.
    Poster abstracts, pp. 127.
  • 2-5 Juin 2010 : EMBO Confrence Series "Microtubules, Structure, Regulation and Functions", European Molecular Biology Laboratory, Heidelberg, Allemagne".
    • Electron cryo-tomography of microtubule assemblies: automatic segmentation of tomograms with CryoSeg
      Blestel S, Fish C., Heichette C., Dupuys-Williams P., Chrétien* D. and C. Kervrann. Poster abstracts, pp. 72.
    • Effects of XMAP215 on microtubule dynamics and structure and its visualization by electron-cryo-tomography
      Coquelle* F., Blestel S., Kinishita K., Vitre B., Heichette C., Kervrann C., Arnal I. and D. Chrétien. Poster abstracts, pp. 97.
    • Three-dimensional reconstruction of 14 protofilaments GMPCPP-microtubules using TubuleJ
      Guesdon* A., Blestel S., Heichette C., Kervrann C. and D. Chrétien. Poster abstracts, pp. 127.
    • Structural basis of the interaction between microtubules and +TIPs
      Arnal* I., Coquelle F., Blestel S., Vitre B., Heichette C., Kervrann C. and D. Chrétien. Speaker abstracts, pp. 38.
  • 28 juin - 1er juillet 2009 : 2009 IEEE International Symposium on Biomedical Imaging: from Nano to Macro.
    Fourier-based method for detecting curved microtubule centers: application to straightening of cryo-electron microscope images
    .
    Blestel*, S., Kervrann, C. and D. Chrétien (Communication orale).
  • 22 - 26 juin 2009 : 11e Colloque de la Société Française des Microscopies, Paris.
    Segmentation of fibers in cryo-electron tomograms.
    Blestel*, S., D. Chrétien, and C. Kervrann (Poster).
  • 27 mai 2009 : Cilia, Flagella and Centrosome Meeting, Paris.
    La morphogénèse du centrosome révélée par cryo-tomographie électronique.
    Guichard*, P., Tassin, A.M., Blestel, S., Kevrann, C., Chrétien, D. and S. Marco (Présentation orale).

Formations

  •  7-17 septembre 2009 : EMBO practical course on image processing for cryo-electron microscopy.
    Institute of Structural and Molecular Biology, Birkbeck, University of London.

Publications

  • Conditional Random Fields for tubulin-microtubule segmentation in cryo-electron tomography
    Kervrann C., Blestel S., and D. Chrétien
    Proceedings of the IEEE International Conference on Image Processing (ICIP 2014), Paris, Pages 1-4,  October 2014

  • Cryo-electron tomography of microtubules assembled in vitro from purified components
    Coquelle F., Blestel S., Heichette C., Arnal I., Kervrann C. and D. Chrétien
    Methods in Molecular Biology, 2011, 777:193-208.
    Pubmed

  • Assessment of standard coil positioning in transcranial magnetic stimulation in depression
    Nauczyciel, C., Hellier, P., Morandi, X., Blestel, S., Drapier, D., Ferre, J.C., Barillot, C. and B. Millet
    Psychiatry research, 2010 (In press).

  • A Fourier-based method for detecting curved microtubule centers: Application to straightening of cryo-electron microscope images
    Blestel, S., Kervrann, C., and D. Chrétien
    Proceedings of the IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2009. pp. 298-301.
    Web link