• Published by: Denis CHRETIEN
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Sophie Blestel

Since 2008

French National Institute for Research in Computer Science and Control (INRIA Rennes - Bretagne Atlantique)

PhD student at INRIA, under the supervision of Charles Kervrann (SERPICO team) and Denis Chrétien (TIPs team, UMR6026):
Extraction of macromolecular assemblies in tomograms obtained by cryo-electron microscopy

2007-2008

Research Institute in Computer Science and Random Systems (IRISA)

  • Master's Degree in signal processing at the University of Rennes 1
    5 months internship in Irisa – Inria, in Vista research project:
    Statistical modelisation and segmentation of 3D images from cryo-electron microscopy

2002-2007

National Institute of Applied Sciences

  •  Engineering school at INSA (National Institute of Applied Sciences), Rennes
    6 months internship in Irisa – Inria, in Visages research project (Vision, action and information management system in health):
    Development of a neuronavigation system for transcranial magnetic stimulation (C++, python)

    • Last semester in Spain, in Universidad Politecnica of Valencia
    • 2006:  3 months placement in AES Chemunex (manufacturer of tools for microbiology laboratories): development of a model of a new tool (C++)
    • 2004-2007: Engineer specialization in Electronic and computer science

Publications

  • Conditional Random Fields for tubulin-microtubule segmentation in cryo-electron tomography
    Kervrann C., Blestel S., and D. Chrétien
    Proceedings of the IEEE International Conference on Image Processing (ICIP 2014), Paris, Pages 1-4,  October 2014.
  • Single versus dual-axis cryo-electron tomography of microtubules assembled in vitro: Limits and perspectives
    Guesdon A., Blestel S., Kervrann C. and D. Chrétien
    Journal of Structural Biology, 2013, 1:169-178.
  • A Fourier-based method for detecting curved microtubule centers: Application to straightening of cryo-electron microscope images
    Blestel, S., Kervrann, C., and D. Chrétien
    Proceedings of the IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2009. pp. 298-301.

Patents

  • TubuleJ (2011)
    IDDN.FR.001.240023.000.S.P.2011.000.21000
    Blestel S., A. Guesdon, C. Kervrann and D. Chrétien
  • Système de neuronavigation pour la stimulation magnétique transcrânienne (2007)
    Blestel S., V. Gratsac, P. Hellier
    IDDN.FR.001.470037.000.S.P.2007.000.31230

Conferences

  • 2-5 Juin 2010 : EMBO Confrence Series "Microtubules, Structure, Regulation and Functions", European Molecular Biology Laboratory, Heidelberg, Germany.
    • Electron cryo-tomography of microtubule assemblies: automatic segmentation of tomograms with CryoSeg
      Blestel S, Fish C., Heichette C., Dupuys-Williams P., Chrétien* D. and C. Kervrann. Poster abstracts, pp. 72.
    • Effects of XMAP215 on microtubule dynamics and structure and its visualization by electron-cryo-tomography
      Coquelle* F., Blestel S., Kinishita K., Vitre B., Heichette C., Kervrann C., Arnal I. and D. Chrétien. Poster abstracts, pp. 97.
    • Three-dimensional reconstruction of 14 protofilaments GMPCPP-microtubules using TubuleJ
      Guesdon* A., Blestel S., Heichette C., Kervrann C. and D. Chrétien. Poster abstracts, pp. 127.
    • Structural basis of the interaction between microtubules and +TIPs
      Arnal* I., Coquelle F., Blestel S., Vitre B., Heichette C., Kervrann C. and D. Chrétien. Speaker abstracts, pp. 38.
  • 28 juin - 1er juillet 2009 : 2009 IEEE International Symposium on Biomedical Imaging: from Nano to Macro, Boston, USA.
    Fourier-based method for detecting curved microtubule centers: application to straightening of cryo-electron microscope images
    Blestel*, S., Kervrann, C. and D. Chrétien (Oral communication).
  • 22 - 26 June 2009: 11th Symposium of the French Society for Microscopies, Paris, France.
    Segmentation of fibers in cryo-electron tomograms
    Blestel*, S., D. Chrétien, and C. Kervrann (Poster).
  • 27 mai 2009 : Cilia, Flagella and Centrosome Meeting, Paris.
    La morphogénèse du centrosome révélée par cryo-tomographie électronique.
    Guichard*, P., Tassin, A.M., Blestel, S., Kevrann, C., Chrétien, D. and S. Marco (Présentation orale).

Training

  • 7-17 september 2009 : EMBO practical course on image processing for cryo-electron microscopy.
    Institute of Structural and Molecular Biology, Birkbeck, University of London.

Publications

  • Conditional Random Fields for tubulin-microtubule segmentation in cryo-electron tomography
    Kervrann C., Blestel S., and D. Chrétien
    Proceedings of the IEEE International Conference on Image Processing (ICIP 2014), Paris, Pages 1-4,  October 2014

  • Cryo-electron tomography of microtubules assembled in vitro from purified components
    Coquelle F., Blestel S., Heichette C., Arnal I., Kervrann C. and D. Chrétien
    Methods in Molecular Biology, 2011, 777:193-208.
    Pubmed

  • Assessment of standard coil positioning in transcranial magnetic stimulation in depression
    Nauczyciel, C., Hellier, P., Morandi, X., Blestel, S., Drapier, D., Ferre, J.C., Barillot, C. and B. Millet
    Psychiatry research, 2010 (In press).

  • A Fourier-based method for detecting curved microtubule centers: Application to straightening of cryo-electron microscope images
    Blestel, S., Kervrann, C., and D. Chrétien
    Proceedings of the IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2009. pp. 298-301.
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