• Published by: Claire HEICHETTE
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Claire Heichette

Phone +33 (0)2 23 23 68 41

2012: UMR 6290 Institute of Genetics and Development of Rennes, University of Rennes 1, France

  • Research technician, University of Rennes 1.
  • Team "Tubulin and Interacting Proteins".

1999-2011: UMR 6026 Cell and Molecular Interactions, Rennes 1 University, France

  • Since 2007: Team "Tubulin and Interacting Proteins".
    • 2007: Research technician in electron microscopy.
  • 2004-2007: Team "Structure and Dynamics of Macromolecules".
  • 1999-2003: Teams "Structure and Dynamics of the Cytoskeleton" and "Channels and Membrane Receptors".
    • 1999: Research technician in Biology.

1995-1999: Nantes University, France

  • Technician in Biology, Nantes University.
  • 1997: Technician Diploma in Biochemistry (BTS), Professional and Technological High School Talensac, Nantes.


  • 2006: Introduction to transmission electron microscopy for biologists, chemists, and physicists (Pierre & Marie Curie University, Paris).
  • 2005: Cellular tomography (Pierre & Marie Curie University, Paris).
  • 2004: Transmission electron microscopy (Angers University).
  • 2003: Confocal microscopy (Rennes 1 University).
  • 2002: Molecular biology (Poitiers University).
  • 1999: Introduction to genetics engineering (Rennes 1 University).


  • Trehalose prevents aggregation of exosomes and cryodamage
    Bosch S., de Beaurepaire L., Allard M., Mosser M., Heichette C., Chrétien D., Jegou D., and J.-M. Bach Scientific Reports, 2016, 6:36162.
    Scientific Reports
    - SharedIt

  • EB1 interacts with outwardly curved and straight regions of the microtubule lattice
    Guesdon A., Bazile F., Buey R.M., Mohan R., Monier S., Rodríguez García R., Angevin M., Heichette C., Wieneke R., Tampé R., Duchesne L., Akhmanova A., Steinmetz M.O., and D. Chrétien
    Nature Cell Biology, 2016, Sept 12
    Pubmed - Springer Nature Sharing

  • Cryo-electron tomography of microtubules assembled in vitro from purified components
    Coquelle F., Blestel S., Heichette C., Arnal I., Kervrann C. and D. Chrétien
    Methods in Molecular Biology, 2011, 777:193-208.

  • The 90-kDa heat shock protein HSP90 protects tubulin against thermal denaturation
    Weis, F., Moullintraffort, L., Heichette, C., Chrétien, D., and C. Garnier
    The Journal of Biological Chemistry
    , 2010, 285:9525-34.

  • Mercury (Drosophila Tubulin Binding Cofactor B) controls cell polarity through the stabilisation of the microtubule network
    Baffet, A., Benoit, B., Gourhand, V., Heichette, C., Chrétien, D., and A. Guichet
    Mechanisms of Development, 2009, 126:S147-S148.

  • Second harmonic microscopy of axonemes
    Odin, C., Heichette, C., Chrétien,D., and Y. Le Grand
    Optics Express, 2009, 17:9235–9240.
    Pubmed PDF (1.2 MB)

  • EB1 regulates microtubule dynamics and tubulin sheet closure in vitro
    Vitre, B., Coquelle, F. M., Heichette, C., Garnier, C., Chrétien, D. and I. Arnal
    Nature Cell Biology, 2008, 10:415-421.

  • CLIP-170/tubulin-curved oligomers coassemble at microtubule ends and promote rescues
    Arnal, I., Heichette, C., Diamantopoulos, G. S. and D. Chrétien
    Current Biology, 2004, 14:2086-2095


  • Single versus dual-axis cryo-electron tomography of microtubules assembled in vitro: Limits and perspectives
    Guesdon A., Blestel S., Kervrann C. and D. Chrétien
    Journal of Structural Biology, 2013, 1:169-178.
  • Pore selectivity analysis of an aquaglyceroporin by stopped-flow spectrophotometry on bacterial cell suspensions
    Hubert J. F., Duchesne L., Delamarche C., Vaysse A., Gueune H., and C. Raguenes-Nicol
    Biology of the Cell, 2005, 97:675-686
  • Mosquito Aedes aegypti  aquaporin present in tracheolar cells, transports water, not glycerol, and forms orthogonal arrays in Xenopus oocyte membranes
    Duchesne L., Hubert J. F., Verbavatz J. M., Thomas D. and P. V. Pietrantonio
    European Journal of Biochemistry, 2003, 270:422-429
  • Role of C-terminal domain and transmembrane helices 5 and 6 in function and quaternary structure of MIP proteins. Analysis of Aquaporin/Glycerol facilitator chimeric proteins
    Duchesne L., Pellerin I., Delamarche C., Deschamps S., Lagree V., Froger A., Bonnec G., Thomas D., and J. F. Hubert
    Journal of Biological Chemistry, 2002, 277:20598-20604
  • Oligomerization of water and solute channels of the major intrinsic protein (MIP) family
    Duchesne L., Deschamps S., Pellerin I., Lagrée V., Froger A., Thomas D., Bron P., Delamarche C. and J. F. Hubert
    Kidney International, 2001, 60:422-426